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KMID : 1145520160020010009
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Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 1 p.9 ~ p.16
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Recent advances in carbon-11 chemistry
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Lu Yingqing
Lee Byung-Chul
Kim Sang-Eun
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Abstract
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Carbon-11 is one of the most sensitive and desirable positron emission tomography radio-isotope, which offers the capacity to be incorporated, through a covalent bond, into biologically active molecules without altering their biological properties. Carbon-11 can be obtained from the cyclotron with two different chemical forms: [11C]CO2 and [11C]CH4. [11C]Methyl iodide has been widely used as a highly reactive labelling precursor that can be applied to label carbon-11 with biologically active molecules via alkylation of N-, O-, or S-nucleophiles. A more recent and still challenging labeling method is transition metal mediated 11C-carbonylation. Advances in organic chemistry, radiochemistry and improved automated techniques greatly encourage researchers to develop more carbon-11 labelled radiotracers for molecular imaging studies. This mini-review will introduce a historical track of carbon-11 chemistry combining with examples and its role in near future.
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KEYWORD
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Carbon-11, Radiochemisty, PET, 11C-carbonylation, [11C]CO2 fixation
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